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                          教授

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                          胡曉玉

                          時間:2019-03-07來源:材料科學與技術學院點擊:1179

                          姓名: 胡曉玉       性別:                  職務:

                          職稱: 教授         導師類別:碩士生導師      辦公室:1號樓902

                          研究領域:有機功能材料、納米藥物載體、超分子自組裝、超分子聚合物材料

                          電話: 18761895025                   Email:huxy@nuaa.edu.cn

                          個人簡介:

                          胡曉玉教授20116月畢業于中科院成都生物所,獲藥物化學理學博士學位;20117月—20136月,南京大學博士後,20137月評爲副研究員;20166月-20185月,德國杜伊斯堡-埃森大學,洪堡高級訪問學者(Humboldt Fellowship for Experienced Researcher);20186月起聘爲南京航空航天大學教授,研究方向爲有機超分子材料化學,主要涉及超分子組裝,功能材料及納米藥物載體方面的研究。研究工作以分子設計合成爲基礎,以分子識別與超分子可控組裝爲手段,以有機功能材料構築爲導向,旨在實現系列新型“智能”有機超分子組裝體系的可控構築及其功能化。

                          近年主持国家自然科学基金面上项目和青年项目各一项,江苏省优青项目和青年基金项目各一项,主持德国洪堡基金项目和南京市留学人员科技創新项目(A類)各一項。先後在包括J. Am. Chem. Soc., Nat. Commun., Angew. Chem. Int. Ed.,Acc. Chem. Res., Chem. Mater., Small等國際高影響力刊物上發表SCI論文60余篇。研究成果目前已被SCI引用2600次,單篇最高引用380余次。2018獲得江蘇省教育教學與研究成果獎(三等獎,排名第三),以及江蘇省科學技術獎一等獎(第七完成人)。擔任江蘇省化學化工學會大環與超分子專業委員會青年委員;並受邀擔任國際SCI學術期刊“RSC Advance”和“Frontiers in Chemistry”的通訊編委,以及“Chinese Chemical Letters”的青年編委。

                          學術成果:

                          代表性文章

                          1).    S. Wang, Z. Xu, T. Wang, T. Xiao, X.-Y. Hu(*), Y.-Z. Shen(*), L. Wang(*). Warm/cool-tone switchable thermochromic material for smart windows by orthogonally integrating properties of pillar[6]arene and ferrocene. Nat. Commun., 2018, 9, 1737. (IF=12.35)

                          2).    S. Guo, Y. Song, Y. He,X.-Y. Hu(*), L. Wang(*). Highly efficient artificial light-harvesting systems constructed in aqueous solution based on supramolecular self-assembly, Angew. Chem. Int. Ed., 2018, 57, 3163-3167. (IF=12.10)

                          3).    X.-Y. Hu(*), L. Gao, S. Mosel, M. Ehlers, E. Zellermann, H. Jiang, S. K. Knauer, L. Wang, C. Schmuck.* From supramolecular vesicles to micelles: Controllable construction of tumor-targeting nanocarriers based on host–guest interaction between a pillar[5]arene-based prodrug and a RGD-sulfonate guest. Small,2018, 14, 1803952. (IF=9.60)

                          4).    M. Zuo, W. Qian, Z. Xu, W. Shao, X.-Y. Hu(*), D. Zhang(*), J. Jiang(*), X. Sun, and L. Wang(*). Multi-responsive supramolecular theranostic nanoplatform based on pillararene and diphenylboronic acid derivatives for integrated glucose sensing and insulin delivery, Small, 2018, 14, 1801942.(IF=9.60)

                          5).    M. Zuo, W. Qian, T. Li, X.-Y. Hu,* J. Jiang,* L. Wang.* Full-color tunable fluorescent and chemiluminescent supramolecular nanoparticles for anti-counterfeiting inks, ACS Appl. Mater. Interfaces, 2018, 10, 39214-39221. (IF=8.10)

                          6).    W. Shao, X. Liu, G. Sun, X.-Y. Hu,(*) J.-J Zhu, L. Wang. Construction of drug-drug conjugate supramolecular nanocarriers based on water-soluble pillar[6]arene for combination chemotherapy. Chem. Commun., 2018, 54, 9462-9465. (IF=6.29).

                          7).    Z. Xu, S. Wang, X.-Y. Hu,(*) J. Jiang,(*) X. Sun, L. Wang.(*) Sunlight-induced photo-thermochromic supramolecular nanocomposite hydrogel film for energy-saving smart window. Solar RRL, 2018, 1800204.

                          8).    X.-Y. Hu(*), M. Ehlers, T. Wang, E. Zellermann, S. Mosel, H. Jiang, J.-E. Ostwaldt, S. K. Knauer, L. Wang, C. Schmuck.* Formation of twisted β-sheet tapes from a self-complementary peptide based on novel pillararene-GCP host-guest interaction with gene transfection properties. Chem.―Eur. J.,2018, 24, 9754-9759. (IF=5.16)

                          9).    X. Liu, K. Jia,Y. Wang, W. Shao, C. Yao, L. Peng, D. Zhang(*), X.-Y. Hu(*), L. Wang. Dual-responsive bola-type supra-amphiphile constructed from water-soluble pillar[5]arene and naphthalimide-containing amphiphile for intracellular drug delivery. ACS Appl. Mater. Interfaces, 2017, 9. 4843-4850. (IF=8.10)

                          10).X. Liu, W. Shao, Y. Zheng, C. Yao, L. Peng, D. Zhang, X.-Y. Hu(*), L. Wang.GSH-Responsive supramolecular nanoparticles constructed by β-D-galactose-modified pillar[5]arene and camptotecin prodrug for targeted anticancer drug delivery. Chem. Commun., 2017, 53, 8596-8599. (IF=6.29)

                          11).L. Gao, T. Wang, K. Jia, X. Wu, C. Yao, W. Shao, D. Zhang, X.-Y. Hu(*), L. Wang(*). Glucose-responsive supramolecular vesicles based on water-soluble pillar[5]arene and pyridylboronic acid derivative for controlled insulin delivery. Chem.―Eur. J.,2017, 23, 6605-6614. (IF=5.16)

                          12).S. Guo, T. Liang, Y. Song, M. Cheng, X.-Y. Hu(*), J.-J. Zhu(*), L. Wang(*). Supramolecular Polymersomes Constucted from Water-soluble Pillar[5]arene and Cationic Poly(glutamamide)s and Their Applications for Targeted Anticancer Drug Delivery. Polym. Chem., 2017, 8, 5718-5725. (IF=4.93)

                          13).X.-Y. Hu, X. Liu, S. Qin, W. Zhang, C. Yao, Y. Li, D. Cao, L. M. Peng, L. Wang(*). Controllable construction of biocompatible supramolecular micelles and vesicles by water-soluble phosphate pillar[5,6]arenes for selective anti-cancer drug delivery, Chem. Mater., 2016, 28, 3778-3788. (IF=9.89)

                          14).S. Guo, X. Liu, C. Yao, C. Lu, X.-Y. Hu(*), L. Wang(*). Photolysis of a bola-type supra-amphiphile promoted by water-soluble pillar[5]arene-induced assembly, Chem. Commun., 2016, 52, 10751-10754. (IF=6.29)

                          15).X. Wu, Y. Yu, L. Gao, X.-Y. Hu,* L. Wang.* Multi-responsive supramolecular gel constructed by pillar[5]arene-based pseudo[2]rotaxanes via orthogonal metal-ligand coordination and hydrogen bonding interaction, Org. Chem. Front., 2016, 3, 966-970. (IF=5.46)

                          16).X. Wu, L. Gao, X.-Y. Hu(*) L. Wang. Supramolecular drug delivery systems based on water-soluble pillar[n]arenes, Chem. Rec., 2016, 16, 1216-1227. (IF=4.89)

                          17).Y. Cao, Y. Li, X.-Y. Hu(*), X. Zou,S. Xiong, C. Lin, L. Wang(*). Supramolecular nanoparticles constructed by DOX-based prodrug with water-soluble pillar[6]arene for self-catalyzed rapid drug release, Chem. Mater., 2015, 27, 1010-1019. (IF=9.89)

                          18).   X.-Y. Hu, Y. Cao, Y. Li, K. Jia, S. Qin, F. Zhou, C. Lin, D. Zhang, L. Wang(*). Dual photo- and pH-responsive supramolecular nanocarriers based on water-soluble pillar[6]arene and different azobenzene derivatives for intracellular anticancer drug delivery, Chem. Eur. J.,2015, 21,1208-1220. (IF=5.16)

                          19).X. Wu, M. Ni,W. Xia,X.-Y. Hu(*) L. Wang. A novel dynamic pseudo[1]rotaxane based on mono-biotin-functionalized pillar[5]arene, Org. Chem. Front., 2015, 2, 1013-1017.( IF=5.46)

                          20).X. Wu, Y. Li, C. Lin, X.-Y. Hu(*), L. Wang(*). GSH- and pH-responsive drug delivery system constructed by water-soluble pillar[5]arene and lysine derivative for controllable drug release, Chem. Commun., 2015, 51, 6832-6835. (IF=6.29)

                          21).L.-B. Meng, D. Li, W. Zhang, Y. Li, X.-Y. Hu(*), L. Wang(*), G. Li. pH-Responsive supramolecular vesicles assembled by water-soluble pillar[5]arene and BODIPY photosensitizer for chemo-photodynamic dual therapy, Chem. Commun., 2015, 51, 14381-14384. (IF=6.29)

                          22).   X.-Y. Hu, T. Xiao, C. Lin, F. Huang, L. Wang(*). Dynamic supramolecular complexes constructed by orthogonal self-assembly, Acc. Chem. Res., 2014, 47, 2041-2051. (IF=20.96)

                          23).Y. Cao(#), X.-Y. Hu(#), Y. Li, X. Zou,S. Xiong, C. Lin, Y.-Z. Shen, L. Wang(*). Multistimuli-responsive supramolecular vesicles based on water-soluble pillar[6]arene and SAINT complexation for controllable drug release, J. Am. Chem. Soc., 2014, 136, 10762-10769 (共同一作). (IF=14.36)

                          24).J. Wu, S. Sun, X. Feng, J. Shi, X.-Y. Hu(*), L. Wang(*). Controllable aggregation-induced emission based on a tetraphenylethylene-functionalized pillar[5]arene via host-guest recognition, Chem. Commun., 2014, 50, 9122-9125. (IF=6.29)

                          25).M. Ni, X.-Y. Hu(*), J. Jiang(*), L. Wang. The self-complexation of mono-urea-functionalized pillar[5]arenes with abnormal urea behaviors, Chem. Commun., 2014, 50, 1317-1319. (IF=6.29)

                          承擔項目:

                          主持國家自然科學基金:

                          1)腫瘤靶向性超分子囊泡體系的設計、構築及應用研究;2016-2019

                          2)基于柱芳烴聚輪烷的絕緣分子導線的合成與性質研究;2013-2015

                          主持江蘇省基金:

                          1)智能超分子納米組裝體的構築及其功能化研究;2018-2021

                          2)基于柱芳烴的超分子囊泡體系的構築及其在藥物轉運方面的應用;2015-2017

                          主持德國洪堡基金項目;2016-2018

                          主持南京市留学人员科技創新项目(A類);2019.01-2019.12

                          主持中央高校985苗圃項目及中國博士後面上基金項目;2012-2013


                          地址:江蘇省南京市江甯區將軍大道29號

                          南京航空航天大學材料科學與技術學院

                          郵編:211106

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